![]() Select the Initial Estimates tab in the lower panel.Įxtend the Duration to 15, since the last observed timepoint is 14 hours.Įnter values 2, 300, and 0.1 for tvKa, tvV, and tvKe, respectively. The NLME engine will not generate its own initial estimates, like the WNL Classic engine can, so it is important to consider reasonable starting values. Notice that the warning about Aa values is gone and the tab label now says “no warnings.” In the Columns tab below the table, select Aa from the Columns list and enter ng in the Unit field.Ĭlick X in the upper right corner to close the source window (the units are added to the column header). However, since the concentration units were ng/mL, the dose should be entered as 2000ng so the units are equivalent. In this example, a single dose of 2 micrograms was administered at time zero. This will be taken care of in the next few steps. Click the WARNINGS tab and note the message that Aa values are missing. If there are no issues, the tab will be labeled “no warnings”. The WARNINGS tab at the bottom highlights potential issues. Use the option buttons in the Main Mappings panel to map the data types to the following contexts: In the first untitled menu, select 3 (1cp extravascular). The first of the two untitled menus allows users to select a PK model, and the second allows users to select a PD model. The contents of the Structure tab changes. In the Structure tab, uncheck the Population box. Right-click the study1 worksheet in the Data folder and select Send To > Phoenix Modeling > Phoenix Model. Select Initial Estimates in the Setup panel list.Ĭlick OK to accept the default sort variable in the Select sorts dialog.Įnter the following information in the table:įor row 1 (V_F), enter 0.25 in the Initial column.įor row 2 (K01), enter 1.81 in the Initial column.įor row 3 (K10), enter 0.23 in the Initial column. The WinNonlin Bounds option is selected by default as the Parameter Boundaries. Select the User Supplied Initial Parameter Values option. Select the Parameter Options tab below the Setup panel. While Phoenix can compute initial parameter estimates using curve stripping, this example will provide user values for the initial parameter estimates. In the Weighting/Dosing Options tab below the Setup panel, type ug in the Unit field.Īll model estimation procedures benefit from initial estimates of the parameters. Select the Dosing panel in the Setup tab.Ĭheck the Use Internal Worksheet checkbox.Ĭlick OK in the Select sorts dialog to accept the default sort variable. In the Model Selection tab below the Setup panel, check the Number 3 model checkbox.Įntering the units for dosing data makes it possible to view and adjust units for the model parameters. With the new PK Model object selected in the Object Browser, drag the study1 worksheet from the Data folder to the Main Mappings panel. Right-click Workflow in the Object Browser and select New > WNL 5 Classic Modeling > PK Model. Set up a PK Model object and a Phoenix Model object, for comparison. This model is available as Model 3 in the pharmacokinetic models included in Phoenix. The plots suggests that the system might be adequately modeled by a one-compartment, 1st order absorption model. The XY Plot is automatically updated to reflect the scale change. Select the Logarithmic option button in the Scale area. In the Options tab below the plot, select Axes > Y from the menu tree. The results are displayed on the Results tab. Leave Subject mapped to the None context.Ĭlick to execute the object. Right-click Workflow in the Object Browser and select New > Plotting > XY Plot.ĭrag the study1 worksheet from the Data folder to the XY Data Mappings panel. ![]() In the File Import Wizard dialog, select the Has units row option and click Finish. Import the file …\Examples\WinNonlin\Supporting files\study1.CSV. The completed project ( PK_Model.phxproj) is available for reference in …\Examples\WinNonlin. This example is about creating and saving PK models in Phoenix and supposes that a researcher has obtained concentration data from one subject after oral administration of a compound, and now wishes to fit a pharmacokinetic (PK) model to the data. Simulation and study design of PK models example Loess regression in phoenix winnonlin how to#Knowledge of how to do basic tasks using the Phoenix interface, such as creating a project and importing data, is assumed. ![]()
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